The core mechanism of yeast cell wall action

      The core mechanism of yeast cell wall action (β - glucan+mannan dual core, divided into general basic mechanism and animal/ruminant differential mechanism)

      The key active components of yeast cell wall: inner layer β - glucan, outer layer mannan (MOS)+a small amount of protein/chitin, the two core components work together.

1、 General Basic Core Mechanism

1. β - glucan: immune activation+anti stress+antioxidant
1) Targeted activation of immunity
      β - glucan binds to the Dectin-1 receptor on the surface of animal immune cells, activating the NF - κ B pathway and promoting the secretion of cytokines such as IL-2, IL-6, TNF - α, etc;
      Enhance macrophage phagocytic ability, NK cell activity, strengthen non-specific immunity, and improve vaccine antibody potency.

2) Relieve various types of stress
      Reduce cortisol concentration during transportation, weaning, group switching, and cold and hot stress, and minimize the decrease in feed intake and production performance caused by stress.

3) Antioxidant and organ protection
      Activate the Nrf2 antioxidant pathway, increase SOD and GSH Px activity, reduce MDA, alleviate oxidative damage, and protect the hepatic intestinal barrier.

2. Mannan/Mannan oligosaccharides MOS: controlling pathogens+optimizing gut/rumen+prebiotics
1) Pathogenic bacteria 'occupying adsorption' (physical inhibition, no drug resistance)
      The MOS structure complements the type I pili of intestinal pathogenic bacteria (such as Escherichia coli, Salmonella, Clostridium perfringens, etc.), competitively binds to the bacteria, prevents them from adhering to the intestinal wall, and excretes them with feces, reducing diarrhea and intestinal inflammation.

2) High quality prebiotics
      Selective feeding of beneficial bacteria such as lactic acid bacteria, bifidobacteria, and rumen fiber degrading bacteria to promote their proliferation and regulate their microbial community structure.

3) Repair mucosal barrier
      Enhance the height of intestinal villi, reduce crypt depth, thicken intestinal mucosa, reduce endotoxin infiltration into the bloodstream, and lower the inflammatory load of the body.

3. Additional function: Fungal toxin adsorption
      The porous network structure of the cell wall can physically adsorb mycotoxins such as aflatoxin and zearalenone, reducing toxin induced liver and kidney damage and production inhibition.

2、 Differentiation mechanism of different breeding categories
✅  Monogastric animals (chickens, pigs)
      Focusing on intestinal health and systemic immunity: reducing diarrhea, improving survival rate, and enhancing feed conversion rate;
There is no rumination rumen degradation problem, and the ordinary wall breaking type can take effect.

✅  Ruminant animals (cows/beef cattle/calves, key differences)
      1) Stable rumen microbiota: MOS promotes the growth of propionic acid producing bacteria and fiber degrading bacteria, and enhances the digestibility of crude fiber in silage/straw; Inhibit excessive accumulation of lactic acid, stabilize rumen pH, prevent rumen acidosis and hoof leaf inflammation;

      2) Improve dry matter intake (DMI) and allocate more nutrients for milk production/weight gain;

      3） ⚠️  The cell wall of ordinary yeast is easily degraded by rumen microorganisms and must pass through the rumen for active ingredients to reach the intestine and exert immune and protective effects.

✅  aquatic products
      Enhance the stress resistance and pathogen resistance of fish and shrimp, improve their survival rate under water stress, and adsorb water toxins.

3、 Summarize the core link in one sentence
      β - glucan has strong immunity and anti stress properties; Mannan inhibits harmful bacteria, nourishes beneficial bacteria, protects mucous membranes and stabilizes the rumen; Collaborative reduction of disease damage, improvement of food intake, enhancement of digestion and utilization efficiency, ultimately improving the efficiency of aquaculture production, without resistance, residue or antibiotic resistance.